Kwambukiranya sodium hyaluronate gel yo kubaga


Ibisobanuro birambuye

Ibiranga ibicuruzwa

Ubuvumbuzi bwa none bufitanye isano na geliyumu ya sodium hyaluronate kugirango yuzuze tissue yo kubaga plastike nuburyo bwo kuyitegura.Umuti wa alkaline ya sodium hyaluronate ukorana numurongo muremure alkane urimo epoxy group hamwe na agent ihuza ihuza amatsinda ya epoxy mumasaha 2˜5 kuri 35 ° C.˜50 ° C. kugirango ikore sodium hyaluronate ihuza, hanyuma ikarabe, gelled na sterisile, kugirango bategure gel.Muri byo, igipimo cya molar ya sodium hyaluronate: guhuza ibikorwa birimo epoxy group: urunigi rurerure alkane irimo epoxy group ni 10: 4˜1: 1˜4;umubare wa atome ya karubone yavuzwe murwego runini alkane irimo epoxy groupe ni 6 kugeza kuri 18. Gele yateguwe muriki gihangano irashobora, kuruhande rumwe, kongera imbaraga zo kurwanya enzymolysis kugirango ihamye, kurundi ruhande, ikomeza biocompatibilité nziza ya sodium hyaluronate itagize ingaruka ku kuyitera.

Gela ihuza sodium hyaluronate gel yo kubaga plastique yo kubaga nuburyo bwo kuyitegura :

Ivumburwa rifitanye isano nuburyo bwo gutegura bwa sodium hyaluronate ihuza cross yo kubaga plastique yo kubaga, irangwa no gutera intambwe zikurikira:
(1) Ifu yumye ya Sodium hyaluronate yakwirakwijwe muri 10?wt% ~ 20?Igisubizo kivanze kigizwe na wt% sodium hydroxide yumuti wamazi na acetone byakoreshejwe kugirango haboneke sodium hyaluronate yibanze, hanyuma uhuze 1,4?Butanediol diglycidyl ether BDDE ivanze neza kugirango ibone ibikoresho bya reaction, kugirango utangire reaction yo kubyara sodium hyaluronate;Mugihe gikangura, reaction irangira nyuma yibikoresho byabitswe bibitswe kuri 35 ℃ ~ 50 ℃ kumasaha 5 ~ 8, hamwe nigiciro cya pH cyibintu bivanze-bivanze nyuma yo kubyitwaramo bigashyirwa kuri 7 hamwe na aside hydrochloric yibanze;Aho kwibumbira hamwe kwa sodium hyaluronate mubikoresho bya reaction ari 2?Wt% ~ 5wt%, igipimo rusange cyibintu bihuza na sodium hyaluronate ni (1: 1.3) ~ (1: 1.8);
.Ibikoresho bisigaye byogejwe na acetone kuri GC?MS kugirango umenye ibiri muri BDDE munsi ya 2ppm.Ibikoresho bisigaye birimo ifu yera na gel ibonerana, hanyuma ibikoresho byumye ni vacuum yumishijwe kugirango ubone ifu yumye idashobora gushonga, ni ukuvuga ifu ya sodium hyaluronate.
.
. shakira sodium hyaluronate gel.
.Nyuma yo kuyungurura, PBS yakuweho hanyuma gel irakusanywa.Gele yagenzuwe ikurikiranye ukoresheje ibisobanuro bya mbere nibisobanuro bya kabiri bya ecran.Habonetse ingano 3 zitandukanye za geles, hanyuma geles 3 zarahinduwe hanyuma zuzuzwa siringi yabanjirije.


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